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2.6 P53 The p53 protein serves a critical role in the cellular response to iron overload, maintaining a balanced state of iron by finely regulating the transcriptional activity of specific genes ( Moreover, p53 is not only involved in iron homeostasis regulation but also enhances the cellular antioxidant defense system by activating the expression of a series of antioxidant enzymes, including GSTs, HO-1, and superoxide dismutase (SOD) ( When the skin is exposed to harmful environmental factors, such as ultraviolet rays, the p53 protein promptly activates its protective mechanism ( Moreover, p53 plays a pivotal role in combating skin aging

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In bladder cancer cells under high-glucose conditions, lactylation of YTHDC1 downregulates JunD proto-oncogene, AP-1 transcription factor subunit and reduces Nectin4 expression, thereby diminishing the sensitivity of the cells to the Nectin4-targeted antibody-drug conjugate, enfortumab vedotin (55)

Engineered microbial nanohybrids for tumor-mediated NIR II photothermal enhanced ferroptosis/cuproptosis and immunotherapy

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